Harvard's AI helps cells recover from illness.

Researchers at Harvard Medical School have created PDGrapher, a free AI model that identifies gene and medication combinations that can restore healthy cells to diseased ones. The specifics: Unlike standard approaches that evaluate one drug target at a time, PDGrapher looks at how genes, proteins, and biological signals interact. When evaluated across 19 cancer kinds, the tool performed 35% better than comparable AI systems and provided answers 25 times faster. The technique was confirmed by researchers by properly identifying known lung cancer medicines and prospective novel targets. Through collaborations with Massachusetts General Hospital, Harvard scientists are using the technique to discover cures for brain disorders like Parkinson's and Alzheimer's. Nowadays, the majority of medications only target one part of the body, but complicated illnesses frequently outsmart these one-trick strategies. By simultaneously identifying several pressure points, PDGrapher may be able to cure diseases that have proven unresponsive to treatment, potentially saving billions of dollars that would otherwise be wasted on fruitless drug trials.